Laboratory of Traumatic and Toxic Lesions in the Nervous System |
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Sean Ingram Patterson
Physiology, School of Medicine, UNC
Associate Researcher in CONICET.
Tel: 54 + 261 + 4135006 Extension: 2684
Fax: 54 + 261 + 4494117
In this laboratory we focus on the formation and function of membrane-associated signalling complexes in axon terminals and astrocytes in different kinds of neural lesions. Many signalling systems form multimeric complexes associated with membrane subdomains at the plasma membrane or on internal structures in response to external signals associated with growth, differentiation, survival and neurotransmission. The postranslational modification of proteins by lipids, particularly the process known as S-palmitoylation, has been proposed to play an important role in the formation and specification of these domains. Our research is directed towards illuminating the physiological role of this process during brain development and in response to specific forms of traumatic and toxic injury in the peripheral and central nervous system
Laboratory Members:
Graduate students:
Virginia Gonzalez Polo (CONICET)
Sergio Laurito (UNSL)
Luis Savastano (UNC)
Undergraduate Students:
Marcos Fitt (UNC)
Valentín Maldonado (UNC)
Recent Publications:
Moore, C.D., Thacker, E.E., Larimore, J., Gaston, D., Underwood, A., Kearns, B., Patterson, S.I., Jackson, T., Chapleau, C., Pozzo-Miller , L. y Theibert, A. (2007). "Centaurin alpha- 1, a Neuronal Arf GAP, Modulates Dendritic Differentiation". J. Cell Science 120: 2683-2693.
Valdez, S. R., Patterson, S. I., Ezquer, M. E., Lama, M. C. and Seltzer, A. M. (2007). "Transient and regional changes in GAP-43 and SNARE protein immunoreactivity in developing rat synaptic terminals after sublethal postnatal hypoxia". Synapse 61: 124-137
Patterson, S. I. (2002). "Posttranslational protein S-palmitoylation and the compartmentalization of signaling molecules in neurons". Biological Research 35: 139-150.
Patterson, S. I. and J. H. P. Skene (1999). "A shift in protein S-palmitoylation, with persistence of growth-associated substrates, suggests a critical period for synaptic plasticity in developing brain". J. Neurobiology 39: 423-437.
Hess, D.T., Smith, D.S., Patterson, S.I., Kahn, R.A., Skene, J.H.P. and Norden, J.J. (1999): "Rapid arrest of axon elongation by brefeldin A: a role for the small GTP-binding protein ARF in neuronal growth cones". J. Neurobiology 38: 105-115.
Grant Support:
Director of the submitted project PIP 2010-2012 "Formation and function of membrane-associated supramolecular complexes in neuronal degeneration and regeneration". Consejo Nacional de Investigaciones Científicas y Tecnológicas (CONICET).
Director of the project 06/J323 "Role of submembrane domains in response to nervous system damage". Consejo de Investigaciones de la Universidad Nacional de Cuyo (CIUNC, 2009-2011).
Director of the project 06/J267 "Formation of intracellular signalling complexes in neuronal degeneration and regeneration". Consejo de Investigaciones de la Universidad Nacional de Cuyo (CIUNC, 2007-2009).
Team member in the project PME-2006-00306 "Consolidation of a network of Cell Biology laboratories for the resolution of human and animal health problems". Agencia Nacional de Promoción Científica y Tecnológica (ANPCyT). Director: María Isabel Colombo.
Director of the project PIP 5123 "Formation of signalling complexes and protein palmitoylation in nervous system development and regeneration". Consejo Nacional de Investigaciones Científicas y Tecnológicas (CONICET, 2006 -2008).
National and International Collaborations:
1) Neurobiology Group IHEM-CONICET. Dr Estela Muñoz Dr. Alicia SeltzerDr. Miguel Sosa
2) Dr. Andrew Quest, Instituto de Ciencias Biomédicas, Universidad de Chile. Caveolin palmitoylation and the formation of supermolecular signalling complexes in neural development and regeneration.
3) Dr. Lisette Leyton, Instituto de Ciencias Biomédicas, Universidad de Chile. Role of Thy-1 and a v b 3 -integrin in the inhibition of central nervous system regeneration after axotomy.
4) Dr. Anne Theibert, Developmental regulation of Arf/Centaurin signalling in the central nervous system.
Teaching:
Undergraduate Course "Funcionamiento del Organismo", 2nd year medical students, Facultad de Ciencias Médicas, Universidad Nacional de Cuyo. 2000-present.
Postgraduate Course "Discussion of Scientific Papers in English", graduate students, ICBM, Faculty of Medicine, Universidad de Chile. 2006-present.
Others:
Member of the Advisory Committee on Building and Biosecurity, Faculty of Medical Sciences, Universidad Nacional de Cuyo. 2008-present.
Actualizado Octubre 2009